FactorSplat: Appearance-Controllable Gaussian Proxies for Medical Volume Rendering

Transfer functions (TFs) control color and visibility in medical volume rendering, but image-trained Gaussian proxies typically bake one transfer function into their appearance. We present FactorSplat, a per-scene N-dimensional Gaussian splatting (N-DGS) proxy that accepts region-specific intensity-to-RGBA curves at inference. A local lookup applies the authored color and opacity change, while a shared functional encoder and low-rank per-Gaussian factors learn the residual appearance response. Geometry and directional appearance remain shared across presets, with visibility control and TF-aware pruning preserving the ability to hide and reveal structures. On seven CT and MR scans, FactorSplat improves mean PSNR and changed-region error over region-aware VEG across validation, interpolation, unseen composition, and out-of-distribution (OOD) edits. Across these four splits, seven-scan mean PSNR gains over VEG range from 1.10 to 1.52 dB. One checkpoint per scan supports unseen edits without retraining. At $1600^2$, the cached fast renderer averages 524 FPS with 1.17 ms TF switches. Project page: https://gaozhongpai.github.io/FactorSplat/.